What Being Sedentary Does to Your Brain—and Why Moving More Matters
Dr. David Perlmutter, MD, board-certified neurologist, and New York Times bestselling author of Brain Defenders — offered commentary on how chronic physical inactivity drives cognitive decline and dementia risk through metabolic and inflammatory pathways, including specific insight into microglia function and mitochondrial health. He also shared practical guidance on breaking up sedentary time, explaining how exercise boosts BDNF and supports neuroplasticity and cerebral blood flow. His input positioned him alongside Dr. Manisha Parulekar as one of the piece’s lead sources on brain-health science.
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Source: Real Simple
Posted on: August 11, 2026